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Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats
L Vécsei1, J Tajti, P Klivényi
1Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary. vecsei@nepsy.szote.u-szeged.hu
Abstract:
Sodium azide (20mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the alpha-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for alpha-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.