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Updated: Aug 10, 2026
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Prophylaxis of Venous Thrombosis
1Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. sgoldhaber@partners.org
Summary
Low molecular weight heparin is recommended for venous thromboembolism prophylaxis, especially after hospital discharge and for high-risk patients. Further attention is needed for prophylaxis failures in intensive care and neurosurgical patients.
Area of Science:
- Vascular Medicine
- Thrombosis Prevention
- Medical Device Efficacy
Background:
- Mechanical prophylaxis (compression stockings, boots) has compliance issues.
- Plantar pneumatic compression devices lack proven efficacy.
- Inferior vena cava filters do not prevent thrombosis.
Purpose of the Study:
- To review current venous thrombosis prophylaxis methods.
- To identify areas for improvement in prophylaxis strategies.
- To advocate for enhanced prophylaxis in specific patient populations.
Main Methods:
- Review of existing mechanical and pharmacologic prophylaxis.
- Analysis of limitations and failures in current practices.
- Expert opinion on future prophylaxis standards.
Main Results:
- Low molecular weight heparin is favored over unfractionated heparin for prophylaxis.
- Extended prophylaxis post-discharge is crucial.
- Prophylaxis failures occur despite adherence, particularly in ICU and neurosurgical patients.
Conclusions:
- Low molecular weight heparin should become the standard pharmacologic prophylaxis.
- Prolonged prophylaxis is essential for high-risk patients, including those in skilled nursing facilities and post-orthopedic surgery.
- Addressing prophylaxis failures in complex patient groups and improving hospital culture are critical for preventing venous thromboembolism.
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