Quantitative Analysis of Indocyanine Green Angiographic Image in Central Serous Chorioretinopathy

Purpose: To disclose the possible involvement of choroidal vascular change in developement of central serous chorioretinopathy (CSC).Methods: Indocyanine green (ICG) angiography was performed in 31 eyes with acute CSC, and 21 eyes from normal subjects. The maximum diameter of the choroidal veins and intensity of background fluorescence in the posterior fundus with ICG video images were measured for further analysis using IMAGEnet((R)) (Topcon). Then the results from CSC affected eyes, their fellow eyes, and normal eyes were compared. Aging factors were taken into consideration when we analyzed the data.Result: The maximum diameters of the choroidal veins were larger in both affected and fellow eyes than in the normal eyes (P <.001), and had a positive correlation with aging particularly in fellow eyes (r = 36). Both in the affected and fellow eyes, the background fluorescein intensity in the posterior pole of the late phase images was lower than in the normal eyes (P <.001), and was correlated with aging (r = 0.28, r = 0.43).Conclusion: This quantitative study showed that choroidal venous dilatation and the residual background fluorescence in the posterior fundus might be positive findings reflecting the pathogenesis of CSC.