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Updated: Aug 15, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Abstract:
Extracts of Acacia longifolia yielded two major histamine aldaloiks which were separated by tlc. Nmr, ms, uv, ir and other physical measurements led to structural assignments of the compounds as N-(2-imidazol-4-yl-ethyl)-trans-cinnamamide and N-(2-imidazol-4-yl-ethyl)-deca-trans-2, cis-4-dienamide. Confirmation of these structures was by comparison of literature data in the case of the cinnamamide and by synthesis of the new decadienamide. Dowex-50 ion exchange resin (H+ form) was found to be highly efficient in the isolation of these compounds from crude plant extracts.
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