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Related Experiment Videos

Hemostatic activation in acute ischemic stroke.

E Berge1, P Friis, P M Sandset

  • 1Hematological Research Laboratory, Department of Hematology, Ullevål University Hospital, N-0407, Oslo, Norway. eivind.berge@ulleval.no

Thrombosis Research
|May 9, 2001
PubMed
Summary

Hemostatic system activation, indicated by D-Dimer and F1+2 levels, correlates with acute ischemic stroke severity. Low levels of coagulation inhibitors and antiphospholipid antibodies are common in stroke patients.

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Area of Science:

  • Neurology
  • Hematology
  • Thrombosis

Background:

  • The hemostatic system plays a crucial role in thrombosis and hemostasis.
  • Understanding hemostatic activation in acute ischemic stroke is vital for patient management.
  • Previous studies have suggested a link between coagulation and stroke, but further data is needed.

Purpose of the Study:

  • To investigate the relationship between hemostatic activation markers and stroke severity.
  • To characterize hemostatic variables in patients presenting with acute ischemic stroke.
  • To explore potential associations between hemostatic factors and stroke etiology or risk factors.

Main Methods:

  • Prospective study of 76 consecutive acute ischemic stroke patients.
  • Measurement of hemostatic variables (D-Dimer, F1+2, antithrombin, protein C, protein S) from blood samples.

Related Experiment Videos

  • Assessment of stroke severity using Oxfordshire Community Stroke Project (OCSP) classification, Barthel Index (BI), and modified Rankin Scale (mRS).
  • Statistical analysis using multiple linear regression to determine associations.

    • Main Results:

    • Elevated D-Dimer and prothrombin fragment 1 + 2 (F1+2) levels were significantly associated with increased stroke severity (OCSP, BI, mRS).
    • Patients with a presumed embolic stroke source showed higher D-Dimer and F1+2, and lower antithrombin and protein C levels.
    • Low levels of protein C or S, and antiphospholipid antibodies (including lupus anticoagulant) were observed in a notable proportion of patients.

    Conclusions:

    • Hemostatic system activation is independently linked to acute ischemic stroke severity and short-term outcomes.
    • The findings highlight the frequent presence of coagulation inhibitors' low levels or antiphospholipid antibodies in acute stroke patients.
    • While these findings are common, a direct causative role in this study could not be established.