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Monocular elevator paresis in neurofibromatosis type 2
R A Egan1, C R Thompson, M MacCollin
1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA.
Neurology
|May 9, 2001
Summary
Monocular elevator paresis is a common finding in neurofibromatosis type 2 (NF2). This condition may indicate third nerve schwannomas, often seen in NF2 patients.
Area of Science:
- Ophthalmology
- Neurology
- Genetics
Background:
- Neurofibromatosis type 2 (NF2) is a genetic disorder characterized by the development of tumors, primarily schwannomas.
- Neuro-ophthalmic complications are potential manifestations of NF2.
Observation:
- A retrospective review examined 29 patients diagnosed with NF2 who underwent neuro-ophthalmic evaluation.
- Four patients (13.8%) presented with monocular elevator paresis.
Findings:
- Magnetic Resonance Imaging (MRI) revealed lesions consistent with third nerve schwannomas in two of the four affected patients.
- Monocular elevator paresis appears to be a frequent neuro-ophthalmic sign in NF2 patients.
Implications:
- The findings suggest that monocular elevator paresis in NF2 patients may be indicative of third nerve infiltration or compression by schwannomas.
- Early recognition of this sign can aid in the diagnosis and management of NF2-related complications.
