Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Germ cell tumor associated primitive neuroectodermal tumors.

K N Ganjoo1, R S Foster, H Michael

  • 1Division of Hematology-Oncology, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana, USA.

The Journal of Urology
|May 9, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Instrumental variable estimation of the marginal structural Cox model for time-varying treatments.

Biometrika·2023
Same author

A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.

American journal of physiology. Lung cellular and molecular physiology·2018
Same author

Discussion of "A risk-based measure of time-varying prognostic discrimination for survival models," by C. Jason Liang and Patrick J. Heagerty.

Biometrics·2016
Same author

TGF-β-mediated airway tolerance to allergens induced by peptide-based immunomodulatory mucosal vaccination.

Mucosal immunology·2015
Same author

Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.

The pharmacogenomics journal·2014
Same author

A multicenter phase II study of pazopanib in patients with advanced gastrointestinal stromal tumors (GIST) following failure of at least imatinib and sunitinib.

Annals of oncology : official journal of the European Society for Medical Oncology·2013

Primitive neuroectodermal tumor (PNT) mixed with germ cell tumors requires aggressive treatment. Retroperitoneal lymph node dissection is recommended for stage I PNT, while metastatic PNT necessitates surgical resection for better outcomes.

Area of Science:

  • Oncology
  • Urologic Oncology
  • Pathology

Background:

  • Primitive neuroectodermal tumor (PNT) admixed with germ cell tumors (GCTs) presents a unique diagnostic and therapeutic challenge.
  • Understanding the prognostic implications and treatment responses in these rare tumors is crucial for patient management.

Purpose of the Study:

  • To evaluate the prognosis and treatment response in patients with primitive neuroectodermal tumor admixed with germ cell tumor.
  • To determine the optimal management strategy for different stages of this rare tumor type.

Main Methods:

  • Retrospective review of 40 patients diagnosed with PNT admixed with GCTs between 1984 and 1999.
  • Analysis of initial disease stage (Stage I vs. metastatic), treatment modalities (surgery, chemotherapy), and patient outcomes.

Related Experiment Videos

  • Median follow-up of 25 months.

    • Main Results:

    • 15 patients had Stage I disease; 9 treated with retroperitoneal lymph node dissection (RPLND) had no recurrence, while 6 on surveillance had a 5/6 relapse rate.
    • 25 patients had metastatic disease; only 3/23 achieved complete remission with chemotherapy alone.
    • Post-chemotherapy RPLND in metastatic cases led to 11/25 patients achieving no evidence of disease, with PNT in the resected specimen indicating a poorer prognosis.

    Conclusions:

    • Primitive neuroectodermal tumor in the orchiectomy specimen is a significant adverse prognostic factor.
    • Retroperitoneal lymph node dissection is potentially curative for retroperitoneal PNT, whereas chemotherapy is rarely effective.
    • Aggressive surgical resection, including RPLND for Stage I and as an integral part of therapy for metastatic disease, is recommended.