Related Experiment Video

Updated: Aug 12, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
15:32

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Published on: August 5, 2011

Identification of poor responders to erythropoietin among children undergoing hemodialysis

W Seeherunvong1, L Rubio, C L Abitbol

  • 1Division of Pediatric Nephrology, University of Miami/Jackson Children's Hospital, Miami, Florida, USA.

The Journal of Pediatrics
|May 9, 2001
PubMed

Insights

Children on hemodialysis needing high doses of recombinant human erythropoietin (rHuEPO) are often younger, smaller, and have infections or severe hyperparathyroidism. High rHuEPO doses may increase heparin needs during dialysis.

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Dialysis Medicine

Background:

  • Anemia is common in children undergoing hemodialysis.
  • Recombinant human erythropoietin (rHuEPO) is used to treat anemia.
  • Identifying factors for high rHuEPO doses is crucial for effective management.

Purpose of the Study:

  • To determine factors associated with high recombinant human erythropoietin (rHuEPO) dose requirements in pediatric hemodialysis patients.
  • To investigate adverse effects linked to high-dose rHuEPO therapy.

Main Methods:

  • Retrospective analysis of clinical data from 23 pediatric hemodialysis patients.
  • Comparison of patients receiving high-dose (≥450 U/kg/wk) versus average-dose rHuEPO.
  • Statistical analysis including Mann-Whitney, Fisher exact, and linear regression tests.

Main Results:

  • 17% of patients required high-dose rHuEPO despite iron repletion.
  • Factors associated with high-dose rHuEPO included younger age, smaller body weight, frequent infections, high ferritin, and severe hyperparathyroidism.
  • Two patients with HIV infection needed high-dose rHuEPO.
  • Increased heparin requirement during hemodialysis was the primary adverse effect of high-dose rHuEPO.

Conclusions:

  • Age, body weight, inflammatory markers, and hyperparathyroidism severity influence rHuEPO dosing in pediatric hemodialysis.
  • High rHuEPO doses may correlate with increased heparin usage in this population.
Abstract

More Related Videos

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells14:22

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...