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Updated: Jul 25, 2026
06:51
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Central venulitis in pediatric liver allografts
A M Krasinskas1, E D Ruchelli, E B Rand
1Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4283, USA.
Hepatology (Baltimore, Md.)
|May 9, 2001
Summary
Isolated central venulitis (ICV) affects 16% of pediatric liver transplant recipients. This condition in children does not appear linked to common causes like recurrent disease or drug toxicity.
Area of Science:
- Pediatric Hepatology
- Transplant Pathology
- Immunology
Background:
- Central venulitis (CV) is a known liver transplant lesion, but its isolated form (ICV) is less understood.
- Etiologies in adults include drug toxicity, rejection, viral hepatitis, ischemia, and recurrent disease.
- Pediatric liver recipients are less prone to recurrent disease and viral hepatitis, necessitating a distinct characterization of ICV in this population.
Observation:
- A 4-year review of pediatric liver allograft biopsies identified ICV in 16% of recipients (7 of 45).
- ICV manifested significantly later post-transplantation than isolated portal rejection.
- No significant correlation was found between ICV and Tacrolimus levels, CMV status, cold ischemic times, or outflow obstruction.
Findings:
- In pediatric liver recipients, ICV is not significantly associated with recurrent disease, viral hepatitis, drug toxicity, or graft ischemia.
- Therapeutic responses to ICV were variable, with some cases resolving and others persisting or recurring.
Implications:
- ICV in pediatric liver transplant recipients is a distinct entity, potentially a variant of acute rejection.
- Further research with longer follow-up is needed to establish optimal therapeutic strategies for ICV in children.
- Understanding ICV's unique characteristics in pediatric populations is crucial for improving transplant outcomes.
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