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Related Experiment Videos

Familial benign recurrent vertigo.

A K Oh1, H Lee, J C Jen

  • 1Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA.

American Journal of Medical Genetics
|May 9, 2001
PubMed
Summary
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Familial benign recurrent vertigo (BRV) is strongly associated with migraine, suggesting it is a migraine syndrome. Vertigo may be a better genetic marker than migraine due to its lower prevalence.

Area of Science:

  • Neurology
  • Genetics
  • Ophthalmology

Background:

  • Benign recurrent vertigo (BRV) has been anecdotally linked to migraine.
  • No previous studies have investigated the familial occurrence of BRV.
  • Understanding the genetic basis of BRV is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the familial aggregation of benign recurrent vertigo (BRV).
  • To determine the relationship between BRV and migraine within families.
  • To explore the potential inheritance pattern of familial BRV.

Main Methods:

  • Studied families of 24 probands presenting with BRV and a family history of vertigo.
  • Probands underwent diagnostic evaluation and completed questionnaires on vertigo and migraine.

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  • Questionnaires were administered to participating relatives (n=220) and unrelated spouses (n=43).

    • Main Results:

    • 37% of relatives reported BRV, and 50% met migraine diagnostic criteria.
    • Only 2% of spouses reported BRV, and 23% met migraine criteria.
    • Over two-thirds of relatives with BRV also met migraine criteria, often experiencing headaches with vertigo.

    Conclusions:

    • Familial BRV appears to be a migraine syndrome.
    • The condition likely follows autosomal dominant inheritance with reduced male penetrance.
    • Vertigo may serve as a more effective genetic marker than migraine for BRV research due to its rarity.