Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms.

A R Tabrizi1, S D McGrath, M A Blinder

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

American Journal of Hematology
|May 9, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to 'Single and binary ion sorption equilibria of monovalent and divalent ions in commercial ion exchange membranes' [Water Research 175 (2020) 115681].

Water research·2021
Same author

Single and binary ion sorption equilibria of monovalent and divalent ions in commercial ion exchange membranes.

Water research·2020
Same author

Combination therapy in relapsed or refractory chronic immune thrombocytopenia: a case report and literature review.

Journal of clinical pharmacy and therapeutics·2016
Same author

Ethical considerations in the collection of genetic data from critically ill patients: what do published studies reveal about potential directions for empirical ethics research?

The pharmacogenomics journal·2009
Same author

Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine.

Histology and histopathology·2007
Same author

Rituximab for the treatment of patients with very high-titre acquired factor VIII inhibitors refractory to conventional chemotherapy.

Haemophilia : the official journal of the World Federation of Hemophilia·2007

Genetic variations in cytochrome P450 (CYP) enzymes significantly impact warfarin metabolism. Two siblings with extreme warfarin sensitivity shared a unique CYP genotype, highlighting the role of genetics in drug response and the potential of genetic testing for personalized warfarin dosing.

Area of Science:

  • Pharmacogenomics
  • Drug Metabolism
  • Cytochrome P450 Enzymes

Background:

  • Warfarin, a widely used anticoagulant, exhibits significant inter-individual variability in dose response.
  • Warfarin metabolism is primarily influenced by cytochrome P450 (CYP) enzymes, specifically CYP2C9 and CYP1A2.
  • Understanding genetic factors affecting CYP activity is crucial for optimizing warfarin therapy.

Observation:

  • Two siblings presented with an unusually high sensitivity to warfarin.
  • These individuals possessed a rare and specific cytochrome P450 (CYP) genotype.
  • Their clinical presentation suggested a significant genetic influence on warfarin pharmacokinetics.

Findings:

  • The siblings' extreme warfarin sensitivity was directly linked to their uncommon CYP genotype.

Related Experiment Videos

  • This case demonstrates the critical role of genetic makeup in determining an individual's response to warfarin.
  • The identified CYP genotype likely results in altered warfarin metabolism.

    • Implications:

    • Genetic testing for CYP genotypes may predict warfarin sensitivity or resistance.
    • Personalized warfarin dosing guided by pharmacogenetics can improve treatment efficacy and safety.
    • This research underscores the potential of genetic screening to guide anticoagulant prescribing practices.