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Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
A R Tabrizi1, S D McGrath, M A Blinder
1Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
American Journal of Hematology
|May 9, 2001
Abstract:
Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.