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Updated: Aug 8, 2026
08:08
Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
Published on: September 22, 2017
Bronchospasm induced by cardiopulmonary bypass
S Kawahito1, H Kitahata, K Tanaka
1Department of Anesthesiology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Summary
Severe bronchospasm occurred in a teen after cardiopulmonary bypass (CPB). Aggressive bronchodilator therapy successfully treated this rare event, possibly linked to CPB factors.
Area of Science:
- Cardiology
- Anesthesiology
- Pulmonology
Background:
- Cardiopulmonary bypass (CPB) is a critical procedure for cardiac surgeries.
- Severe bronchospasm is an uncommon complication during or after CPB.
- Pulmonary stenosis requires surgical intervention, often involving the right ventricle outflow tract.
Observation:
- A 16-year-old female with pulmonary stenosis experienced sudden, severe bronchospasm post-cardiac surgery.
- High inspiratory airway pressures were noted immediately after initiating partial CPB.
- The patient's lungs became non-compliant, preventing manual ventilation.
Findings:
- Fiberoptic bronchoscopy excluded tracheobronchial obstruction.
- A diagnosis of severe bronchospasm was established.
- The bronchospasm was effectively managed with aggressive bronchodilator therapy.
Implications:
- This case highlights a rare but serious complication of CPB.
- Potential triggers include complement activation or allergic reactions during CPB.
- Further research is needed to understand and prevent bronchospasm in patients undergoing CPB.
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