Physical stabilization of DNA-based therapeutics
Related Experiment Video
Updated: Oct 7, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
Published on: October 25, 2018
T J. Anchordoquy1, S D. Allison, M d.C. Molina
1School of Pharmacy, University of Colorado, 80262, Denver, CO, USA
Abstract:
The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a marketable pharmaceutical product. Here, we describe the different strategies that have been used to enhance stability and discuss the mechanisms by which prolonged stabilization (>2 years) might be achieved.
Related Concept Videos
Single-Strand DNA Binding Proteins
Restarting Stalled Replication Forks
Overview of DNA Repair
Chemically...
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
Drugs that Stabilize Microtubules

