Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet transplantation and glucose regulation.

D W Gray1

  • 1Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. derek.gray@surgery.oxford.ac.uk

World Journal of Surgery
|May 10, 2001
PubMed
Summary

Islet transplantation shows promise for diabetes treatment but faces challenges with limited islet yield and long-term graft function. Rodent models demonstrate successful glucose metabolism with sufficient islet mass.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Islet cell transplantation for insulin-dependant diabetes mellitus: perspectives from the present and prospects for the future.

Expert reviews in molecular medicine·2003
Same author

An overview of the immune system with specific reference to membrane encapsulation and islet transplantation.

Annals of the New York Academy of Sciences·2002
Same author

Transplantation of mouse pancreatic islets into primates--in vivo and in vitro evaluation.

Transplantation·2002
Same author

Rising incidence of post-transplant lymphoproliferative disease in kidney transplant recipients.

The British journal of surgery·2001
Same author

Xenogeneic islets transplanted into primates are subject to a form of hyperacute rejection independent of anti-GAL-alpha 1-->3 gal antibody binding.

Transplantation proceedings·2001
Same author

Low dose aspirin as prophylaxis against renal-vein thrombosis in renal-transplant recipients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2000

Area of Science:

  • Endocrinology
  • Transplantation Biology
  • Metabolic Diseases

Background:

  • Islet transplantation is an emerging therapy for diabetes, showing limited success in humans.
  • Challenges include poor islet yield and suboptimal graft function, particularly in allotransplantation and autotransplantation.
  • Current intraportal transplantation sites show limited long-term graft survival, often deteriorating within 5 years.

Purpose of the Study:

  • To review the current state of islet transplantation for diabetes treatment.
  • To identify limitations in islet yield and graft function in human and animal models.
  • To explore potential improvements and alternative transplantation sites.

Main Methods:

  • Review of experimental research and clinical applications of islet transplantation.
  • Analysis of factors affecting islet yield and graft survival.
  • Comparison of outcomes across different species and transplantation sites.

Main Results:

  • Human islet transplantation is limited by insufficient islet mass and poor long-term graft function.
  • Alternative sites like spleen or kidney capsule show potential but are limited by islet mass.
  • Rodent models with sufficient islet mass achieve near-normal glucose metabolism and long-term function.

Conclusions:

  • Improving islet yield and long-term graft survival are critical for successful human islet transplantation.
  • Further research into optimal transplantation sites and methods is needed.
  • Rodent models provide valuable insights into achieving functional islet mass equivalence.

Related Experiment Videos