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Insulin pumps and glucose regulation.
1Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, Nebraska 68198-3280, USA.
World Journal of Surgery
|May 10, 2001
Summary
Implantable insulin pumps show promise for diabetes management, with open-loop systems demonstrating safe and effective glucose control. Future research aims to develop closed-loop systems for improved diabetes care.
Area of Science:
- Biomedical Engineering
- Endocrinology
- Medical Devices
Background:
- Recent technological advancements have renewed interest in implantable insulin infusion devices for diabetes management.
- Achieving a fully automated closed-loop system remains a significant challenge in the field.
Purpose of the Study:
- To review the current status and future prospects of implantable insulin infusion devices.
- To assess the safety and efficacy of existing open-loop systems.
Main Methods:
- Review of recent clinical investigations and studies on implantable insulin pump systems.
- Analysis of system components including the pump, delivery catheter, and patient communicator.
Main Results:
- Implantable pumps can be surgically placed with minimal patient morbidity.
- Insulin underdelivery is identified as the primary long-term complication.
- Current implantable pumps show potential for safe and effective glucose control.
Conclusions:
- Open-loop implantable insulin pumps are a viable option for improving diabetes management.
- Further development is needed to create a satisfactory closed-loop implantable system.