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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Soft tissue sarcomas involving the pelvis
S J Lewis1, J S Wunder, J Couture
1University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Department of Surgical Oncology, Toronto, Ontario, Canada.
Journal of Surgical Oncology
|May 10, 2001
Summary
Pelvic soft tissue sarcomas (STS) are rare and aggressive. Despite surgery and radiation, these tumors show a high risk of recurrence and spread, impacting patient outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Radiology
Background:
- Soft tissue sarcomas (STS) of the true pelvis are rare.
- Limited literature exists on pelvic STS, hindering treatment planning and outcome prediction.
Purpose of the Study:
- To understand the anatomical extension of pelvic STS.
- To guide surgical treatment strategies.
- To determine patient outcomes for pelvic STS.
Main Methods:
- Retrospective review of 18 consecutive patients with pelvic STS (1987-1995).
- Minimum follow-up of 18 months.
- Cross-sectional imaging analyzed for tumor location and extension.
Main Results:
- Tumor extension varied: true pelvis (4), retroperitoneum (3), thigh (11).
- Most patients received adjuvant radiation and surgical resection (local or hindquarter amputation).
- High morbidity, positive resection margins (9/18), and poor survival observed (11 deaths, 4 alive with disease, 3 alive without disease).
Conclusions:
- Pelvic STS is a rare but aggressive malignancy.
- High risk of local and systemic disease progression persists despite combined modality treatment.
