Related Experiment Videos
Feeding tolerance of ready-to-use versus powdered formulas in neonates
1Department of Neonatology, Laniado Hospital, Sanz Medical Center, Netanya, Israel. wmeir@hotmail.com
Insights
Ready-to-use infant formula led to more regurgitations in neonates compared to powdered formula. Powdered formula improved feeding tolerance, suggesting differences in preparation impact infant digestion.
Area of Science:
- Neonatal nutrition
- Pediatric gastroenterology
Background:
- Introduction of ready-to-use formula coincided with increased neonatal regurgitation.
- Investigating potential links between formula type and feeding intolerance.
Purpose of the Study:
- Compare feeding tolerance in neonates between ready-to-use and powdered formulas.
- Quantify regurgitations as a measure of feeding tolerance.
Main Methods:
- 727 healthy neonates were divided into six groups.
- Comparison of ready-to-use versus reconstituted powdered formula from two manufacturers.
- A patented feeding bottle (Twist 'N Feed) was used for powdered formula preparation.
Main Results:
- Significantly more regurgitations observed in neonates fed ready-to-use formulas.
- This trend persisted even within a group receiving both formula types.
- Powdered formula demonstrated superior feeding tolerance.
Conclusions:
- Reconstituted powdered infant formula is associated with better feeding tolerance than ready-to-use formula.
- Further research is needed to elucidate the mechanisms behind these observed differences.
Background:
Following the introduction of ready-to-use formula in our neonatal department, we observed an increase in the number of neonates regurgitating after feeding.
Objective:
To compare the feeding tolerance of neonates, in terms of regurgitations, to ready-to-use versus powdered formulas.
Methods:
We compared the number of regurgitations in 727 healthy neonates after feeding ready-to-use formulas and powdered formulas of two different manufacturers. Six groups of neonates were formed, three for each manufacturer. Each of the two groups was fed with either ready-to-use formula or with reconstructed powdered formula (using a two-compartment patented feeding bottle called Twist 'N Feed) and one group received both preparations during 2 successive days.
Results:
The groups that were fed only with ready-to-use formulas had significantly more regurgitations than those fed with powdered formulas. Within the group that received both types of formulas there were significantly more regurgitations following the ready-to-use than the powdered formula.
Conclusions:
Feeding tolerance, in terms of regurgitations, was significantly better in neonates fed reconstituted powdered formula as opposed to ready-to-use formulas. More studies are required to determine the exact mechanism for these differences.