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Effect of salicis cortex extract on human platelet aggregation.
N Krivoy1, E Pavlotzky, S Chrubasik
1Clinical Pharmacology Unit, Rambam Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel. N_Krivoy@rambam.health.gov.il
Planta Medica
|May 11, 2001
Summary
Willow bark extract (Salicis cortex) minimally impacts platelet aggregation compared to aspirin. This study found Salicis cortex extract had a lesser effect on platelet aggregation than acetylsalicylic acid.
Area of Science:
- Pharmacology
- Biochemistry
- Clinical Medicine
Background:
- Salix species bark contains salicin, a precursor to salicylate.
- Salicylate-based compounds are widely used for pain relief.
- The effect of Salix cortex extract on platelet function requires further investigation.
Purpose of the Study:
- To evaluate the impact of Salix cortex extract on platelet aggregation in patients with chronic low back pain.
- To compare the antiplatelet effects of Salix cortex extract with placebo and acetylsalicylate.
Main Methods:
- A double-blind, randomized controlled trial involving 51 patients.
- Patients received either Salix cortex extract (240 mg salicin/day), placebo, or acetylsalicylate (100 mg/day).
- Platelet aggregation was measured using an aggregometer with arachidonic acid, adenosine diphosphate (ADP), and collagen as agonists.
Main Results:
- Acetylsalicylate significantly inhibited platelet aggregation compared to both Salix cortex extract and placebo.
- Salix cortex extract showed a significant reduction in platelet aggregation induced by arachidonic acid and ADP compared to placebo.
- No significant difference in collagen-induced platelet aggregation was observed across the groups.
Conclusions:
- Daily intake of Salix cortex extract (240 mg salicin) has a considerably weaker effect on platelet aggregation than acetylsalicylate.
- The clinical significance of these findings in patients with altered platelet function warrants further research.