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Related Experiment Videos

[Severe malaria].

B Gachot1, F Bruneel, C Behr

  • 1Service de pathologie infectieuse et tropicale Centre médical de l'Institut Pasteur 75724 Paris. bgachot@pasteur.fr

La Revue Du Praticien
|May 11, 2001
PubMed
Summary
This summary is machine-generated.

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Falciparum malaria is a significant threat, especially to African children. Early treatment and prevention are crucial for managing this disease and combating antimalarial drug resistance.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Immunology

Context:

  • Falciparum malaria is a leading cause of death in developing nations, particularly affecting children.
  • France has the highest incidence of imported malaria in Europe.
  • Severe malaria complications include cerebral malaria, shock, acute renal failure, and respiratory distress syndrome.

Purpose:

  • To review the pathophysiology of severe malaria, focusing on cerebral malaria.
  • To discuss current treatment strategies, including the role of quinine and intensive care.
  • To highlight the importance of prevention and early management of uncomplicated malaria.

Summary:

  • Parasitized erythrocytes sequester in the microvasculature, adhering to activated endothelium.
  • Proinflammatory cytokines, such as tumor necrosis factor, contribute to severe disease.

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  • The pathophysiology of cerebral malaria-induced coma is not fully understood.

    • Impact:

    • Effective management of severe malaria relies on early symptomatic treatment in intensive care units.
    • Preventive measures during travel and prompt treatment after return are vital for imported malaria.
    • Developing affordable alternatives to current antimalarials can aid in malaria control in sub-Saharan Africa.