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Pharmacology of moxonidine: an I1-imidazoline receptor agonist
1Department of Nutrition, Case Western University, School of Medicine Cleveland, Ohio 44106, USA.
Journal of Cardiovascular Pharmacology
|May 11, 2001
Abstract:
The I1-imidazoline receptor is a novel neurotransmitter receptor found mainly in the brainstem, adrenal medulla and kidney. The actions of moxonidine are described at the level of individual biomolecules, cells, tissues, organs and finally with integrative functions. The receptor functions at the cellular level works through arachidonic acid and phospholipid signaling cascades in neuronal cells with the net result of inhibiting sympathetic premotor neurons.