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WD-repeat protein encoding genes among prokaryotes of the Streptomyces genus
Z Stoytcheva1, B Joshi, J Spízek
1Laboratory of Physiology and Genetics of Actinomycetes, Institute of Microbiology, Academy of Sciences, Czech Republic, 142 20 Prague 4, Czechia. tichy@biomed.cas.cz
Folia Microbiologica
|May 12, 2001
Abstract:
Southern hybridization with probes designed for detection of WD-repeats coding sequences gave positive results in 21 streptomycete strains indicating that WD-repeats encoding genes are massively spread among streptomycetes. One of them, the wdlA gene of Streptomyces lincolnensis, codes for a 971 amino acid protein with seven WD-repeats in its C-terminus, two transmembrane domains and an ATP/GTP binding site upstream of the WD-repeat region.