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A convenient method for the efficient removal of ruthenium byproducts generated during olefin metathesis reactions
1Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66044, USA.
Organic Letters
|May 12, 2001
Abstract:
[reaction in text] An efficient method for removing ruthenium byproducts generated during olefin metathesis reactions with Grubbs catalysts is described. Treatment of the crude reaction products with triphenylphosphine oxide or dimethyl sulfoxide, followed by filtration through silica gel, was found to be a practical and effective method to remove colored ruthenium byproducts.