Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exploring the relationship between neutral and selective mutations in cancer.

C C Maley1, S Forrest

  • 1Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., N. Seattle, WA 98109, USA. cmaley@alum.mit.edu

Artificial Life
|May 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined effect of toe out gait and high tibial osteotomy on knee adduction moment in patients with varus knee deformity.

Clinical biomechanics (Bristol, Avon)·2017
Same author

Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia.

Molecular human reproduction·2009
Same author

Acceptability of unsupervised HPV self-sampling using written instructions.

Journal of medical screening·2007
Same author

The national review of mental health nursing in Scotland: implications for the profession.

Journal of psychiatric and mental health nursing·2006
Same author

Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22.

Molecular human reproduction·2006
Same author

Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2.

Human biology·2005

Cancer development is an evolutionary process. Simulations show that at least two neutral mutations are needed for cancer, and increasing this number can prevent it, while selective mutations accelerate cancer growth.

Area of Science:

  • Evolutionary biology
  • Cancer research
  • Computational biology

Background:

  • Cancer arises from the accumulation of mutations in cell populations.
  • Cellular evolution involves reproduction, mutation, and competition for resources.
  • Understanding the dynamics of these mutations is key to cancer prevention.

Purpose of the Study:

  • To model the evolutionary dynamics of cancer development.
  • To investigate the roles of neutral and selective mutations in cancer.
  • To explore the impact of a "mutator phenotype" on cancer progression.

Main Methods:

  • Mathematical calculations of cancer probability under simplifying assumptions.
  • Agent-based modeling to simulate cell dynamics and mutation interactions.

Related Experiment Videos

  • Analysis of neutral, selective, and mutator phenotypes in cancer evolution.

    • Main Results:

    • At least two selectively neutral mutations are necessary for cancer development.
    • Preventive treatments are most effective when increasing the number of neutral mutations.
    • Selective mutations accelerate cancer development; more selective mutations increase cancer risk.

    Conclusions:

    • Cancer evolution can be modeled as an interplay of neutral and selective mutations.
    • Targeting neutral mutations or increasing their number is a potential preventive strategy.
    • Understanding mutation dynamics is crucial for developing effective cancer therapies.