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Related Experiment Videos

Diltiazem treatment does not alter renal function after thoracic surgery.

D Amar1, M Fleisher

  • 1Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. amard@mskcc.org

Chest
|May 12, 2001
PubMed
Summary

Diltiazem treatment did not affect kidney function in patients undergoing thoracic surgery. This study found no significant differences in serum creatinine or BUN levels between diltiazem and placebo groups.

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Area of Science:

  • Cardiology
  • Nephrology
  • Thoracic Surgery

Background:

  • Conflicting data exists regarding diltiazem's impact on renal function in surgical settings.
  • Investigated diltiazem's effect on kidney function specifically in major thoracic surgery patients.

Purpose of the Study:

  • To assess whether diltiazem administration alters postoperative renal function.
  • To clarify the safety profile of diltiazem concerning kidney health in this patient cohort.

Main Methods:

  • Prospective study involving 330 patients undergoing elective thoracic surgery.
  • Patients received either intravenous (IV) diltiazem or placebo post-operation for 14 days.
  • Monitored serum creatinine and blood urea nitrogen (BUN) levels pre- and post-surgery.

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Main Results:

  • No significant differences in serum creatinine or BUN levels between diltiazem and placebo groups within the first five postoperative days.
  • Similar baseline characteristics, comorbidities, and surgical factors between groups.
  • Incidence of renal failure was low and not statistically different (0.6% vs 1.2%).

Conclusions:

  • Prophylactic diltiazem treatment does not negatively impact postoperative renal function in patients without pre-existing kidney disease undergoing elective thoracic surgery.
  • Diltiazem appears safe for renal function in this specific surgical context.