Related Experiment Video
Updated: Aug 10, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Clinical correlation with changing radiographic appearance during partial liquid ventilation
D P Schuster1, N R Lange, A Tutuncu
1Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA. schusted@msnotes.wustl.edu
Study Objectives:
To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing.
Design:
Post hoc review of chest radiographs by three independent observers with correlation to clinical variables.
Setting:
Phase II randomized, uncontrolled, prospective, multicenter clinical trial.
Patients:
Sixteen adult patients with diffuse bilateral infiltrates consistent with acute lung injury and a PaO(2)/fraction of inspired oxygen (FIO(2)) ratio < 300 with positive end-expiratory pressure of 13 cm H(2)O and FIO(2) > or = 0.5.
Interventions:
All patients were treated with either a 10-mL/kg or 20-mL/kg loading dose of perflubron followed by maintenance dosing at 3-h intervals to protocol-determined levels.
Results:
There was a significant relationship between inhomogeneous radiographic filling during the first 48 h of treatment and the use of the lower loading dose of perflubron. Inhomogeneous radiographic filling (in 5 patients) was associated with a lower high-dose/FIO(2) ratio at 24 h compared with the remaining patients. These differences resolved by 48 h. There were no other statistically significant correlations identified.
Conclusions:
The radiographic appearance of PLV with perflubron appears to depend on the dose administered. Lower doses can be associated with both inhomogeneous radiographic filling and a transient deterioration in oxygenation during the first 24 to 48 h of treatment.
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