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Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans
M Jertborn1, I Nordström, A Kilander
1Department of Medical Microbiology and Immunology, Department of Gastroenterology, Sahlgrenska University Hospital, Göteborg, Sweden. marianne.jertborn@microbio.gu.se
The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.
The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.