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Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against
C G Feng1, U Palendira, C Demangel
1Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia.
Infection and Immunity
|May 12, 2001
Abstract:
Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.