[March hemoglobinuria. One case with erythrocyte glutathione peroxidase deficiency]

A new case of march haemoglobinuria seen in a 21-year-old man is reported. A deficiency in two erythrocytic enzymes (glutathione reductase and glutathione peroxydase) was observed. Treatment with riboflavin corrected the glutathione reductase deficiency. The march haemoglobinuria and glutathione peroxydase deficiency persisted. Several months after resolution of the march haemoglobinuria, a new estimation of glutathione peroxydase showed that the deficiency had disappeared. The possible role of a transient deficiency in erythrocyte glutathione peroxydase in the pathogenesis of march haemoglobinuria is discussed.