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Updated: Oct 7, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
[Fetal drug addiction as a consequence of maternal cocaine free base abuse during pregnancy]
M Mena1, P Navarrete, S Corvalán
1Servicio de Pediatría, DPG y Unidad de Informática Maternidad, Hospital Dr. Sótero del Río.
Insights
Children exposed to cocaine free base in utero face significant health and developmental challenges, including lower birth weight, developmental delays, and behavioral issues. Urgent prevention strategies are needed to address these severe consequences.
Area of Science:
- Perinatology
- Developmental Pediatrics
- Public Health
Context:
- Fetal drug addiction, particularly to cocaine free base, presents a significant public health concern.
- Over 200 offspring of cocaine free base abusers have been identified in a Chilean health service.
- Prenatal cocaine exposure affects a substantial percentage of children in the United States.
Purpose:
- To investigate the clinical and social characteristics of 100 children exposed to cocaine free base during fetal development.
- To document the immediate and long-term effects of prenatal cocaine exposure on child health and development.
Summary:
- Children exposed to cocaine free base in utero exhibited lower birth weight, a threefold increase in prematurity, and fourfold higher rates of small-for-gestational-age infants.
- Exposed infants showed higher incidences of cardiac malformations, seizures, and apnea, requiring more frequent and complex hospitalizations.
- During follow-up, undernutrition, stunting, psychomotor retardation (67%), and behavioral disturbances (93%) were prevalent, with most children requiring governmental protection.
Impact:
- Findings highlight the critical need for effective strategies to prevent prenatal drug abuse and mitigate its severe medical and social ramifications.
- This study underscores the long-term developmental and health burdens associated with prenatal cocaine exposure.
- The results emphasize the vulnerability of children exposed to substances in utero and the societal responsibility for their care.
Background:
Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of children have been exposed "in utero" to cocaine. In a Chilean public health service, more than 200 offspring of cocaine free base abuser have been detected.
Aim:
To analyze the clinical and social features of 100 children exposed to cocaine free base during fetal development.
Patients And Methods:
Clinical features of children born from cocaine free base consume mothers were described at birth. During subsequent follow up, growth and development, disease episodes, developmental alterations and social situation were recorded. Data was compared with other newborns from the same health service.
Results:
Compared to their normal counterparts, exposed children has a lower birth weight, the frequency of premature babies was thrice higher, and small-for-gestational age children were four times more common. There was also a higher prevalence of cardiac malformations, seizures and apnea. Hospital admissions were more frequent, prolonged and required more complex facilities. During follow up, undernutrition and stunting were more prevalent. Psychomotor retardation was present in 67% of children and behavioral disturbances in 93%. Most of these children are governmental protection.
Conclusions:
Strategies to prevent drug abuse during pregnancy and its devastating medical and social consequences should be urgently developed (Rev Méd Chile 2000; 128: 1093-1100).
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