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Updated: Jul 26, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 27, 2013
[GPIIb/IIIa blockers for optimizing thrombolysis in acute myocardial infarct]
1Abteilung Innere Medizin III (Schwerpunkt Kardiologie und Angiologie), Universitätsklinikum Freiburg. nordt@mm31.ukl.uni-freiburg.de
Background:
Thrombolytic therapy is an established strategy for the treatment of acute myocardial infarction. GPIIB/IIIA BLOCKERS + MODERN THROMBOLYTIC AGENTS: At present, the most attractive development for optimizing thrombolytic therapy includes the use of GPIIb/IIIa blockers in combination with modern thrombolytic agents such as alteplase and reteplase. The review summarizes the available results of clinical studies using standard doses of thrombolytic agents (TAMI 8, IMPACT-AMI, and PARADIGM) or reduced dosages of thrombolytic agents (TIMI 14 and SPEED) for combination therapy. The review also focuses on the implications of the combination therapy for coronary angioplasty immediately following coronary thrombolysis.
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