[Acute limb ischemia]

Related Experiment Video

Updated: Oct 7, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia
07:57

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

S M Schellong1, D Ockert, V Hänig

  • 1Arbeitsbereich Angiologie, Medizinische Klinik III, Universitätsklinik Carl Gustav Carus, Medizinische Fakultät der Tu Dresden. Sebastian.Schellong@mailbox.tu-dresden.de

Herz
|May 15, 2001
PubMed

Insights

Acute limb ischemia requires prompt revascularization to prevent amputation. Even after successful treatment, the limb remains at risk due to the ischemia/reperfusion cascade, necessitating careful patient assessment.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Emergency Medicine

Background:

  • Acute limb ischemia (ALI) presents with diverse clinical signs and symptoms.
  • Embolic occlusion, often cardiac in origin, can lead to complete limb ischemia.
  • Atherosclerotic arterial thrombosis may allow for collateral vessel recruitment, offering a perfusion buffer.

Purpose of the Study:

  • To elucidate the pathophysiology and clinical management of acute limb ischemia.
  • To highlight the critical role of timely revascularization in limb salvage.
  • To underscore the ongoing risks post-revascularization and the importance of comprehensive evaluation.

Main Methods:

  • Pathophysiological analysis of ALI based on embolism and thrombosis.
  • Evaluation of revascularization strategies and their impact on limb salvage.
  • Assessment of diagnostic procedures including angiography and risk stratification.

Main Results:

  • Complete ischemia occurs when an embolus occludes both the primary vessel and existing collaterals.
  • Prompt revascularization is crucial to avert major amputation.
  • The ischemia/reperfusion cascade poses a persistent threat even after successful revascularization.

Conclusions:

  • Understanding ALI pathophysiology guides treatment decisions.
  • Timely intervention and post-procedural vigilance are key to successful limb salvage.
  • Comprehensive evaluation facilitates complex revascularization in high-risk patients.
Abstract

More Related Videos

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...