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Splenic involvement in lymphomas. Evaluation on serial CT examinations
M Daskalogiannaki1, P Prassopoulos, G Katrinakis
1Department of Radiology, University Hospital of Crete, Heraklion, Crete, Greece.
Acta Radiologica (Stockholm, Sweden : 1987)
|May 15, 2001
Summary
Changes in splenic volume (SV) on CT scans can indicate lymphoma progression or remission. Decreased SV suggests treatment response, while increased SV post-therapy may signal recurrence.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Lymphoma often involves the spleen, impacting its size.
- Assessing splenic changes can aid in monitoring disease activity.
Purpose of the Study:
- To prospectively evaluate changes in splenic volume (SV) using serial CT scans in lymphoma patients.
- To correlate SV changes with other disease indicators.
Main Methods:
- Calculated SV from 290 abdominal CT scans of 58 lymphoma patients (non-Hodgkin's and Hodgkin's).
- Performed CT investigations before, during, and after chemotherapy.
- Correlated SV changes with clinical, laboratory (serum lactic dehydrogenase - S-LDH), and imaging data.
Main Results:
- Group A (n=20): Stable SV, no splenic abnormalities, normal S-LDH.
- Group B (n=25): Decreased SV during treatment, indicating response; splenic involvement and S-LDH normalized.
- Group C (n=12): Increased SV post-therapy, associated with disease recurrence and elevated S-LDH.
Conclusions:
- Quantitatively assessed splenic size on CT is a valuable indicator of splenic involvement in lymphoma.
- Serial CT evaluation of SV can help monitor treatment response and detect recurrence.