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Nitric oxide synthesis is decreased in periodontitis

A Aurer¹, J Aleksić, M Ivić-Kardum

¹Department of Periodontal Diseases, Dental School, University of Zagreb, Croatia. aurer@sfzg.hr

Journal of Clinical Periodontology

|May 15, 2001

Abstract

Objectives:

In order to study the possible role of nitric oxide (NO) in the development of periodontitis, we measured the concentration of its stable metabolite nitrite (NO2-) in the saliva of patients with periodontitis and healthy subjects.

Materials And Methods:

We have analysed salivary NO2- concentrations in 25 subjects with rapidly progressive periodontitis (RPP), 25 with adult periodontitis (AP) and in 25 periodontally-healthy persons. The concentrations of NO2- were determined by the Griess reaction in microtitration plates. Periodontal tissue destruction was determined by measuring the attachment level loss using standard methods.

Results:

Subjects with periodontitis had significantly less NO2- in saliva than healthy subjects. Subjects with RPP had lower NO2- concentrations than those with AP Parotid gland saliva contained less NO2- than sublingual gland or total saliva.

Conclusions:

Local NO production is decreased in patients with periodontitis. This effect is more pronounced in those with severe types of disease.

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