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The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
N Prenzel1, O M Fischer, S Streit
1Max-Planck Institut für Biochemie, Department of Molecular Biology, Am Klopferspitz 18A, 82152 Martinsried, Germany.
Abstract:
Homeostasis of multicellular organisms is critically dependent on the correct interpretation of the plethora of signals which cells are exposed to during their lifespan. Various soluble factors regulate the activation state of cellular receptors which are coupled to a complex signal transduction network that ultimately generates signals defining the required biological response. The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases represents both key regulators of normal cellular development as well as critical players in a variety of pathophysiological phenomena. The aim of this review is to give a broad overview of signal transduction networks that are controlled by the EGFR superfamily of receptors in health and disease and its application for target-selective therapeutic intervention. Since the EGFR and HER2 were recently identified as critical players in the transduction of signals by a variety of cell surface receptors, such as G-protein-coupled receptors and integrins, our special focus is the mechanisms and significance of the interconnectivity between heterologous signalling systems.
Insights
Cellular signaling relies on interpreting external cues. This review explores the epidermal growth factor receptor (EGFR) superfamily
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- Multicellular organism homeostasis depends on cellular signal interpretation.
- Cellular receptors and signal transduction networks govern biological responses.
- The epidermal growth factor receptor (EGFR) family is crucial for development and disease.
Purpose of the Study:
- To provide an overview of EGFR superfamily signaling in health and disease.
- To discuss therapeutic interventions targeting EGFR signaling.
- To highlight the interconnectivity between EGFR signaling and other cell surface receptors.
Main Methods:
- Review of existing literature on EGFR signaling pathways.
- Analysis of the role of EGFR and HER2 in signal transduction.
- Examination of cross-talk between EGFR and heterologous signaling systems (GPCRs, integrins).
Main Results:
- EGFR superfamily receptors are key regulators of cellular development.
- EGFR and HER2 play critical roles in signal transduction from various cell surface receptors.
- Interconnectivity between EGFR and other signaling systems is significant in health and disease.
Conclusions:
- Understanding EGFR signaling networks is vital for comprehending cellular function and disease.
- Targeting EGFR pathways offers potential for selective therapeutic interventions.
- The interplay between EGFR and other signaling pathways is a critical area for further research.