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Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent
1Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta - 700 032, India.
Phytotherapy Research : PTR
|May 15, 2001
Summary
Trigonella foenum graecum seed extract demonstrated significant antineoplastic and anti-inflammatory effects. The extract inhibited tumor cell growth by over 70% in the Ehrlich ascites carcinoma (EAC) model.
Area of Science:
- Pharmacology
- Cancer Research
- Immunology
Background:
- Trigonella foenum graecum (fenugreek) is traditionally used for medicinal purposes.
- The antineoplastic and anti-inflammatory properties of fenugreek require further scientific investigation.
Purpose of the Study:
- To evaluate the antineoplastic effect of Trigonella foenum graecum seed extract.
- To assess the anti-inflammatory potential of the extract.
Main Methods:
- The study utilized the Ehrlich ascites carcinoma (EAC) model in Balb-C mice.
- Intra-peritoneal administration of the alcohol extract of Trigonella foenum graecum seeds was employed.
- Tumor cell growth, peritoneal exudate cell counts, and macrophage cell counts were measured.
Main Results:
- The extract demonstrated over 70% inhibition of tumor cell growth compared to controls.
- Treatment with the extract significantly increased peritoneal exudate cell and macrophage counts.
- A notable anti-inflammatory effect was observed.
Conclusions:
- Trigonella foenum graecum seed extract exhibits significant antineoplastic activity against EAC.
- The extract possesses notable anti-inflammatory properties.
- Fenugreek seed extract shows promise as a therapeutic agent for cancer and inflammation.