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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Coronary artery disease in patients with renal failure

D J Goldsmith1, A Covic

  • 1Renal Unit, Guy's Hospital, St Thomas Street, London SE1 9RT, UK.

International Journal of Clinical Practice
|May 16, 2001
PubMed

Insights

Cardiovascular disease is common in advanced kidney disease patients. This review covers risk factors like inflammation and oxidation, and evidence for interventions in this high-mortality group.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiovascular disease (CVD) is a major health concern for patients with advanced renal failure, on dialysis, and post-renal transplantation.
  • Patients with chronic kidney disease (CKD) face a higher risk of CVD due to a combination of traditional and unique risk factors.
  • Inflammation and oxidative stress are implicated in accelerating atherosclerosis in individuals with CKD.

Purpose of the Study:

  • To discuss the contributing factors to cardiovascular problems in patients with advanced kidney disease.
  • To review the evidence supporting cardiovascular interventions and treatments for this patient population.
  • To highlight the significance of inflammation and oxidation in CKD-related atherosclerosis.

Main Methods:

  • Literature review and evidence synthesis.
  • Discussion of conventional and novel cardiovascular risk factors in renal failure.
  • Analysis of studies on cardiovascular intervention and treatment efficacy.

Main Results:

  • Advanced renal failure, dialysis, and transplantation are associated with high CVD prevalence.
  • Inflammation and oxidative stress play a critical role in the progression of atherosclerosis in CKD.
  • Evidence for various cardiovascular interventions in this high-risk group is examined.

Conclusions:

  • Cardiovascular disease management is crucial in patients with advanced kidney disease.
  • Addressing inflammation and oxidative stress may be key to mitigating atherosclerosis.
  • Further research and tailored interventions are needed for this high-mortality population.

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