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Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis

J L Frossard1, C M Pastor, A Hadengue

  • 1Division of Gastroenterology, Geneva University Hospital, 1211 Geneva 14, Switzerland. jean-louis.frossard@hcuge.ch

American Journal of Physiology. Gastrointestinal and Liver Physiology
|May 16, 2001
PubMed

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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