Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endoscopy-negative reflux disease.

J P Galmiche1, S B des Varannes

  • 1Department of Gastroenterology and Hepatology and INSERM U 539, Hôtel-Dieu, CHU Nantes, 44093 NANTES Cedex, France. galmiche@easynet.fr

Current Gastroenterology Reports
|May 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: the diminishing returns of normalisation of the oesophageal mucosa-Authors' reply.

Alimentary pharmacology & therapeutics·2017
Same author

The dynamics of the oesophageal squamous epithelium 'normalisation' process in patients with gastro-oesophageal reflux disease treated with long-term acid suppression or anti-reflux surgery.

Alimentary pharmacology & therapeutics·2017
Same author

Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies.

Alimentary pharmacology & therapeutics·2015
Same author

Randomized clinical trial: effect of the 5-HT4 receptor agonist revexepride on reflux parameters in patients with persistent reflux symptoms despite PPI treatment.

Neurogastroenterology and motility·2014
Same author

Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Endoscopy·2012
Same author

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.

Neurogastroenterology and motility·2012
Same journal

Management of Common Bile Duct Stones: Current Approaches and Evolving Endoscopic Strategies.

Current gastroenterology reports·2026
Same journal

Solitary Rectal Ulcer Syndrome Revisited: A Comprehensive Narrative Review.

Current gastroenterology reports·2026
Same journal

The Microbiome and Esophageal Disease: Where Are We Now?

Current gastroenterology reports·2026
Same journal

Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation.

Current gastroenterology reports·2026
Same journal

A Practical Guide to Incorporating Novel Barrett's Screening/Surveillance Tools into Clinical Practice.

Current gastroenterology reports·2026
Same journal

The Role of Endoscopic Ultrasound in the Diagnosis and Management of Congenital Gastrointestinal and Pancreaticobiliary Conditions.

Current gastroenterology reports·2026
See all related articles

Endoscopy-negative reflux disease (ENRD) significantly impacts quality of life, despite not progressing to erosive stages. Management focuses on symptom relief and quality of life restoration, similar to reflux esophagitis.

Area of Science:

  • Gastroenterology
  • Digestive Health

Background:

  • Endoscopy-negative reflux disease (ENRD) is common, particularly in primary care.
  • It presents as reflux-related symptoms with normal acid exposure, part of the gastroesophageal reflux disease spectrum.
  • ENRD frequently recurs, affecting patients' quality of life.

Purpose of the Study:

  • To review the diagnosis and management of ENRD.
  • To highlight the importance of symptom analysis and the potential role of proton pump inhibitor (PPI) testing.
  • To discuss long-term treatment strategies and future therapeutic directions.

Main Methods:

  • Literature review focusing on diagnosis and management of ENRD.
  • Discussion of diagnostic tools including 24-hour pH monitoring and PPI testing.

Related Experiment Videos

  • Analysis of treatment approaches, including pharmacotherapy and surgery.

    • Main Results:

    • Symptom analysis is crucial for diagnosis, especially in atypical presentations.
    • Proton pump inhibitor (PPI) testing may be a cost-effective alternative to pH monitoring, but requires validation.
    • Proton pump inhibitors (PPIs) show similar or less efficacy in ENRD compared to reflux esophagitis.

    Conclusions:

    • ENRD management aims to restore quality of life using principles similar to reflux esophagitis.
    • Long-term treatment strategies vary (maintenance, intermittent, on-demand) based on patient needs.
    • Future treatments may target transient lower esophageal sphincter relaxation or visceral perception.