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Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa
K Tateda1, R Comte, J C Pechere
1Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.
Antimicrobial Agents and Chemotherapy
|May 17, 2001
Abstract:
We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.