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Glycosidase inhibition by cyclic sulfonium compounds
H Yuasa1, J Takada, H Hashimoto
1Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan. hyuasa@bio.titech.ac.jp
Bioorganic & Medicinal Chemistry Letters
|May 17, 2001
Abstract:
Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha-glucosidase was ascribed to the tether arm.