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Updated: Jul 28, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry
1Procter & Gamble Pharmaceuticals, Healthcare Research Center, Mason, OH 45040, USA. lwilson3@prius.jnj.com
Abstract:
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
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