Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles
P Schumann1, V Collot, Y Hommet
1CNRS UMR 6551, Université de Caen, France. rault@pharmacie.unicaen.fr
Abstract:
The synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented. The 7-methoxyindazole, although less potent than 7-NI, is the most active compound of the series in an in vitro enzymatic assay of neuronal nitric oxide synthase activity. This result shows that the nitro-substitution is not indispensable to the biological activity of the indazole ring. 7-Methoxyindazole possesses in vivo NOS inhibitory as well and related antinociceptive properties.
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