Quinazolines as cyclin dependent kinase inhibitors
T M Sielecki1, T L Johnson, J Liu
1The DuPont Pharmaceuticals Company, Wilmington, DE 19880-0500, USA. thais.m.sielecki@dupontpharma.com
Bioorganic & Medicinal Chemistry Letters
|May 17, 2001
Abstract:
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
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