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The Cell-based L-Glutathione Protection Assays to Study Endocytosis and Recycling of Plasma Membrane Proteins
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NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines

J Oiry1, P Mialocq, J Y Puy

  • 1Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université Montpellier II, Sciences et Techniques du Languedoc, France. oiryj@univ-montp2.fr

Bioorganic & Medicinal Chemistry Letters
|May 17, 2001
PubMed

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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