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Updated: Oct 7, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones
1Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
Bioorganic & Medicinal Chemistry Letters
|May 17, 2001
Abstract:
A series of 2',3',4',6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the asopharynx.
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