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Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality
J F Cavalier1, M Burton, F Dussart
1Unité de Chimie Organique et Médicinale, Université catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.
Bioorganic & Medicinal Chemistry
|May 17, 2001
Abstract:
A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.