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Related Experiment Videos

Developments in ultrasound contrast media.

C J Harvey1, M J Blomley, R J Eckersley

  • 1Department of Imaging, Hammersmith Hospital, Imperial College School of Medicine, Du Cane Road, London W12 ONN, UK. charvey_99@yahoo.com

European Radiology
|May 17, 2001
PubMed
Summary

Ultrasound microbubble contrast agents significantly enhance ultrasound imaging, improving diagnostic accuracy for liver lesions and microcirculation. These agents offer a safe and effective method for advanced functional and quantitative studies.

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Acoustic super-resolution with ultrasound and microbubbles.

Physics in medicine and biology·2013

Area of Science:

  • Medical Imaging
  • Biophysics

Background:

  • Ultrasound microbubble contrast agents are established echo enhancers.
  • Methods are employed to ensure stability and clinical utility.
  • Microbubbles amplify ultrasound signals via resonant behavior, aiding Doppler studies and microcirculation imaging.

Purpose of the Study:

  • To explore the application of ultrasound microbubbles in imaging microcirculation.
  • To investigate functional studies using contrast agent transit.
  • To evaluate the role of microbubbles in detecting liver metastases and cirrhosis.

Main Methods:

  • Utilizing microbubble resonant behavior for signal enhancement.
  • Employing active and passive quantitation techniques for functional studies.
  • Applying non-linear ultrasound modes (e.g., phase inversion, stimulated acoustic emission) for imaging.

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Main Results:

  • Ultrasound enhancement up to 25 dB (300-fold increase) achieved.
  • Successful application in detecting liver metastases and cirrhosis.
  • Demonstrated hepatosplenic specific phase for enhanced ultrasound versatility.
  • Improved sensitivity and specificity in focal liver lesion detection rivaling CT and MR.

Conclusions:

  • Ultrasound microbubbles are versatile tools for enhancing diagnostic imaging.
  • Functional studies with microbubbles show promise for clinical applications, particularly in liver imaging.
  • Non-linear imaging techniques with microbubbles significantly improve detection and characterization of liver lesions.