Related Experiment Video
Updated: Oct 7, 2026
Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
Tobacco usage in relation to the anatomical site of oral leukoplakia
K P Schepman1, P D Bezemer, E H van der Meij
1Department of Oral and Maxillofacial Surgery and Pathology, Academic Hospital Vrije Universiteit/Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands.
Objective:
Tobacco usage is the most important known aetiological factor in the development of oral leukoplakia. The purpose of this study was to investigate the possible relation of tobacco usage to the anatomical site of the leukoplakia.
Subjects And Methods:
Clinical data regarding tobacco usage and localisation of leukoplakia obtained from 166 patients with oral leukoplakia.
Results:
Leukoplakias in the floor of mouth appeared to be statistically significantly more often present in smokers than in non-smokers, compared to all other oral sites (P < 0.001; OR = 8.47 and 18.13 for men and women, respectively). On the contrary, leukoplakias on the borders of the tongue were statistically significantly more common among non-smokers, than smokers, compared to all other oral sites (P < 0.001; OR = 0.22 and 0.12 for men and women, respectively).
Conclusion:
The present study suggests that the influence of tobacco on the development of leukoplakia varies by anatomical site.
Related Concept Videos
01:26Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features