Immunological and biochemical comparison of streptokinase and the streptokinase plasminogen complex

Biochemical and Immunological studies have been made on streptokinase and its one to one molar complex with plasminogen. These experiments show that the complex is not recognized by antibodies to streptokinase. The potential of using this complex in vivo to avoid febrile response seen with streptokinase is considered.