Rheumatological symptoms. Will investigation make a difference?

Many tests are available for investigation and monitoring of rheumatological symptoms, but their usefulness depends on appropriate choice and correct interpretation of the result.

To discuss which investigations are appropriate in assessing a variety of rheumatological symptoms and how to interpret results.

Few of the tests used in the investigation of musculoskeletal symptoms are 'diagnostic'. False positives and false negatives often occur. It is important to interpret the test in the context of the individual patient. Monitoring of diseases is usually based on clinical findings, with investigations only used if they reliably parallel disease activity, monitor drug toxicity, or where changes in the test are likely to lead to modification of management.